Our team
The main research theme of our team (Pathology of DNA replication) is how the deregulation of DNA replication program can induce genetic instability and then lead to human diseases. To answer this question we are interested in both physiological and stressed DNA replication process, like in cancer cells. We use a variety of methods including high-throughput approaches as microarray, ChIP-sequencing and also classical molecular and cellular biology methods as DNA-2D-gel and CrispR-cas9. We also analyse genomic "big data" from various public consortium databases in order to find a relationship between diseases and molecular elements associated with replication. We also develop bioinformatic programs to analyse our results and actually the implementation of bioinformatic tools is an important part of our daily activities.
Giuseppe Baldacci
Emerita
Professor Emeritus of Human Multifactorial Pathologies, I am particularly interested in cancer biology. During my career, I studied genes and proteins implicated in DNA replication and in its regulation during the cell cycle. Together with my colleagues of the team, we think that pathological changes in the controls of DNA replication play an essential role in the vast majority of cancers and constitute excellent targets for tumor therapies.
Jean-Charles Cadoret
Team leader
I am an associated professeur at the Paris-Diderot University and I am the group leader of the "Pathology of DNA replication" team. Daily I perform High-troughput experiments as ChIP-sequencing, Whole genome replication timing program characterization, functional genomic. My interests concern DNA replication and relationship with genomic organization and their impacts on the genetic instability when these processes failled.
Thomas Denecker
PhD studient
I am a PhD student in computational biology and bioinformatics. I realize my thesis under the direction of Gaëlle Lelandais in the BIM team of Institut de Biologie Intégrative de la Cellule (I2BC) directed by Olivier Lespinet.
Fabien Fauchereau
Assistant Professor
I am an associate professor and I teach Human genetics at the Paris-Diderot University. I analyze omic data from cancer databases and test drugs on cellular models.
Djihad Hadjadj
PhD studient
I am a PhD student interested in the mechanisms regulating eukaryotic DNA replication. To do so I use both classic methods (cell culture, Western-blots, qPCRs…) and high-throughput approaches (ChiP-chip, ChIP-sequencing…). I hope that it will help us understand, at least partly, genomic instability in cancer cells.
Su-Jung Kim
PhD studient
PhD student, I'm interested in the molecular and cellular mecanisms of CDK4/6 inhibitors in cancer cell lines. I try to understand their impacts on DNA replication and cellular responses. My aim is to advance personalized cancer therapeutics.
Chrystelle Maric-Antoinat
Researcher
Molecular biologist, I'm interested in eukaryotic DNA replication, replication fork progression and pausing sites. Trying to understand more precisely the replication / transcription coupling and the environment of replication forks pausing and arrest is part of my concerns with the implication of DNA replication in the relationship between genome stability and cancer appearance.